Programs: Biomedical Sciences
- BS, Biology, Colegio Nacional Nicolas Avellaneda
- MD, National University of Buenos Aires, School of Medicine
- Postdoctoral Training, Children's Cancer Research Foundation
I work in collaboration with Ana Soto and her laboratory. Our laboratory works on the control of the initiation of the proliferation of estrogen-target cells. This basic biological question is explored under the fundamental premise that proliferation is the default state of all living cells. We have identified several plasma-borne and endogenously generated inhibitors of cell proliferation. In collaboration with Dr. Ana M. Soto, we have proposed the tissue organization field theory of carcinogenesis, which proposes that carcinogenesis is a tissue-based phenomenon. This notion challenges the one embodied in the somatic mutation theory of carcinogenesis, which posits that an accumulation of mutations in a single cell is responsible for the causation of a neoplasia.
Soto AM, Schaeberle C, Maier MS, Sonnenschein C, Maffini MV. 2017. Evidence of absence: Estrogenicity assessment of a new food-contact coating and the bisphenol used in its synthesis. Environ Sci Technol. 51: 1718-1726.
Speroni L, Voutilainen M, Mikkola ML, Klager SA, Schaeberle CM, Sonnenschein C, Soto AM. 2017. New insights into fetal mammary gland morphogenesis: differential effects of natural and environmental estrogens. Sci Rep. 7: 40806.
Soto AM, Longo G, Noble D. 2016. Preface to "From the century of the genome to the century of the organism: New theoretical approaches". Prog Biophys Mol Biol. 122: 1-3.
Montévil M, Speroni L, Sonnenschein C, Soto AM. 2016. Modeling mammary organogenesis from biological first principles: Cells and their physical constraints. Prog Biophys Mol Biol. Epub ahead of print.
Sonnenschein C, Soto A. 2016. Carcinogenesis explained within the context of a theory of organisms. Prog Biophys Mol Biol. Epub ahead of print.
Soto AM, Longo G, Miquel PA, Montevil M, Mossio M, Perret N, Pocheville A, Sonnenschein C. 2016. Toward a theory of organisms: Three founding principles in search of a useful integration. Prog Biophys Mol Biol. Epub ahead of print.